Growth Projections for Gene Synthesis: 15.8% CAGR and Beyond

Growth Projections for Gene Synthesis: 15.8% CAGR and Beyond


Jun 24, 2024

Blog Biotechnology Growth Projections for Gene Synthesis: 15.8% CAGR and Beyond

The synthetic synthesis of DNA sequences in the lab, or "gene synthesis," has completely changed genomics and biotechnology. Over the past few decades, this subject has grown quickly thanks to technical advancements and rising demand from a variety of businesses. This blog will examine the current status of international markets, the technologies underlying gene synthesis, and its applications.

This blog will examine the technologies underlying gene synthesis, its uses, and the status of international markets at the moment.

Global Market Trends:

Market Growth

The global gene synthesis market has witnessed significant growth, driven by increasing demand for synthetic genes in various applications. According to BCC Research, The global market for Gene Synthesis is estimated to increase from $2.0 billion in 2023 to reach $4.1 billion by 2028, at a compound annual growth rate (CAGR) of 15.8% from 2023 through 2028.

Regional Insights

  • North America: Dominates the industry as a result of significant R&D investments,a sophisticated biotechnology infrastructure, and the presence of important players.
  • Europe: Follows closely, with important contributions from France, Germany, and the United Kingdom.
  • Asia-Pacific: Anticipated to experience the fastest growth rate due to a growing biotech industry in nations like China, India, and Japan, as well as more research and supportive regulations from the government.



Gene Synthesis: Technologies and Global Markets

The global market for Gene Synthesis is estimated to increase from $2.0 billion in 2023 to reach $4.1 billion by 2028, at a compound annual growth rate (CAGR) of 15.8% from 2023 through 2028.

Key Players and Innovations:

Innovations: Twist Bioscience enables high-throughput and reasonably priced gene synthesis through the use of a special silicon-based DNA synthesis platform. This method makes it possible to create intricate gene constructions and sizable gene libraries.

Offerings: The company offers next-generation sequencing (NGS) technologies, gene fragments, and custom gene synthesis. They are renowned for their accuracy, scalability, and quickness while creating DNA.

Innovations: Thermo Fisher Scientific ensures high precision and customisation in their gene synthesis procedures by incorporating cutting-edge technologies like CRISPR-Cas9 and next-generation sequencing.

Offerings: The company provides a broad range of services and goods, including as oligonucleotides, gene editing solutions, cloning, and customized gene synthesis. They supply a significant number of academic institutions and pharmaceutical industries.

Innovations: GenScript offers complete gene synthesis services by utilizing its knowledge of synthetic biology. To create genes, they employ cutting-edge methods like Gibson Assembly and seamless cloning.

Offerings: GenScript offers customized services for protein engineering, peptide synthesis, gene synthesis, and cell line generation. They are renowned for their excellent, dependable, and quick turnaround times.

Innovations: IDT is a leader in the field of custom oligonucleotide synthesis and has extended its offerings to include CRISPR genome editing tools and high-fidelity gene synthesis.

Offerings: The business provides oligonucleotides, CRISPR solutions, qPCR assays, synthetic genes, and other products. IDT is well known for its accuracy, excellence, and wide range of products.

Innovations: High-accuracy gene synthesis services are the main focus of Eurofins Genomics, which also places a major emphasis on quick delivery and quality monitoring. For fidelity and efficiency, they use a variety of cutting-edge synthesis techniques.

Offerings: Eurofins offers services in bioinformatics, DNA sequencing, oligonucleotide synthesis, next-generation sequencing, and custom gene synthesis. For both scientific and commercial uses, they are a reliable source.

Technologies in Gene Synthesis:

  • Oligonucleotide Synthesis

Gene synthesis revolves around the process of oligonucleotide synthesis, which involves the chemical synthesis of small DNA sequences known as oligonucleotides. For longer DNA sequences, these oligonucleotides function as building blocks. The four phases of the synthesis process are usually coupling, oxidation, capping, and deprotection.

  • Polymerase Chain Reaction (PCR)

DNA sequences can be amplified using PCR, a fundamental method. To create longer DNA fragments from oligonucleotides during gene synthesis, PCR can be utilized. This procedure is made more accurate and efficient by variations including assembly PCR and overlap extension PCR.

  • Gibson Assembly

Gibson Assembly is a technique that makes it possible to seamlessly combine many DNA fragments in one process. A variety of enzymes, including ligases, polymerases, and exonucleases, are used to do this. Gibson Assembly is a technique that has gained popularity because it is sturdy and simple.

  • CRISPR-Cas Systems

CRISPR-Cas systems have revolutionized gene synthesis and genome editing, especially CRISPR-Cas9. Targeted gene insertion, deletion, or alteration is possible by precisely cutting DNA sequences with the Cas9 enzyme by guiding it to those specified regions.

  • Error Correction Technologies

Significant problems might arise from mistakes made during the synthesis of DNA, especially in situations where great fidelity is required. In order to detect and fix these mistakes and guarantee the accuracy of synthetic genes, technologies like as next-generation sequencing and high-fidelity DNA polymerases are utilized.

Applications of Gene Synthesis:

  • Medical Research and Therapeutics

The development of vaccinations, gene treatments, and personalized medicine all depend heavily on gene synthesis. Recombinant proteins, therapeutic genes, and model organisms for disease research are all made possible by the use of synthetic genes.

  • Agriculture and Food Production

Gene synthesis is used in agriculture to create genetically engineered crops with better qualities like increased nutritional value, drought tolerance, and pest resistance. Additionally, synthetic biology is used to produce sustainable food sources, such as meat grown in a lab and food additives that have been bioengineered.

  • Industrial Biotechnology

Businesses use gene synthesis to create biofuels, biodegradable polymers, and enzymes. Synthetically engineered microorganisms possess the ability to effectively transform raw materials into valuable industrial products, hence promoting more environmentally friendly and sustainable industrial operations.

  • Environmental Biotechnology

Gene synthesis makes it possible to produce microbes with specific functions, such as waste treatment, pollution degradation, and environmental change monitoring. These artificial creatures can assist in addressing issues like oil spills and plastic pollution.

Challenges and Future Directions:

  • Technical Challenges

Even though gene synthesis has advanced significantly, problems with cost, scalability, and synthesis errors still exist. To get over these obstacles, error correction, automation, and high-throughput methods must continue to progress.

  • Ethical and Regulatory Considerations

Genetic engineering is developing so quickly that it presents ethical and legal issues. For the field to flourish sustainably, it is essential to address biosecurity concerns, create strong regulatory frameworks, and ensure ethical use of gene synthesis technology.

  • Future Prospects

Gene synthesis appears to have a bright future thanks to possible advances in personalized medicine, synthetic biology, and gene editing. The amalgamation of artificial intelligence and machine learning has the potential to enhance synthesis procedures, resulting in genetic engineering that is more accurate and efficient.


Gene synthesis is the cutting edge of biotechnological research, providing previously unheard-of opportunities in a multitude of fields. Gene synthesis will have a greater and greater impact on research, industry, and society as markets and technology develop. This will pave the road for a day when the entire potential of synthetic genes will be realized.

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    Sandeep Singh Negi

    Written By Sandeep Singh Negi

    Sandeep is a Senior Executive in Marketing Operations at BCC Research, proficiently serving as a graphic designer and content creative specialist. His expertise extends to AutoCAD and Revit, and he has made valuable contributions to the event industry with his design skills.

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